Clinical trials in acute lymphoblastic leukemia

Michael Osborn, Australia

Know ALL was pleased to speak to Michael Osborn, Women's and Children's Hospital, Adelaide, AU. We asked, are there any clinical trials focusing on relapse in ALL, what is the future of CAR T-cell therapy clinical trials for ALL, are there any novel agents currently being investigated for ALL, and how can patients get involved in clinical trials?

Osborn starts by discussing the range of clinical trials being conducted across the globe, including a study of inotuzumab ozogamicin plus chemotherapy for children with relapsed B-ALL in Europe. Then, he explains the current issues with CAR T cells, including the manufacturing time and cost, and highlights the newer CAR T cells being developed with strategies such as adding medications (e.g., venetoclax) into treatment to overcome these challenges. He also describes the novel agents being investigated at different stages for ALL, including revumenib for KMT2A-rearranged ALL. Finally, he discusses researcher's efforts to design clinical trials in collaboration with patients and how people can get involved.