How do genetic changes contribute to acute lymphoblastic leukemia development?

Charles Mullighan, USA

Know ALL was pleased to speak to Charles Mulligan, St Jude Children's Research Hospital, Memphis, US. We asked, How do genetic changes contribute to acute lymphoblastic leukemia development?

Mulligan summarizes how genes are involved in the development of acute lymphoblastic leukemia, highlighting genetic predispositions and increased risk in certain groups of people. He discusses the nature of some genetic changes and the environmental factors that may influence the development of acute lymphoblastic leukemia. Finally, he outlines the genetic differences in acute lymphoblastic leukemia for varying ages and how genetic understanding aids the development of more effective treatments.

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